{"id":9835,"date":"2023-04-03T09:15:50","date_gmt":"2023-04-03T13:15:50","guid":{"rendered":"https:\/\/mrm.research.mcgill.ca\/2023\/04\/mrm-insights-transcriptional-rejuvenation-of-aged-muscle-stem-cells-by-a-young-niche-environment\/"},"modified":"2023-04-04T15:25:42","modified_gmt":"2023-04-04T19:25:42","slug":"mrm-insights-rajeunissement-transcriptionnel-de-cellules-souches-musculaires-agees","status":"publish","type":"post","link":"https:\/\/mrm.research.mcgill.ca\/fr\/2023\/04\/mrm-insights-rajeunissement-transcriptionnel-de-cellules-souches-musculaires-agees\/","title":{"rendered":"MRM Insights: Rajeunissement transcriptionnel de cellules souches musculaires \u00e2g\u00e9es"},"content":{"rendered":"
\"\"

Darren Blackburn<\/p><\/div>\n

\"\"

Vahab Soleimani<\/p><\/div>\n

Chaque mois, dans les\u00a0MRM Insights<\/a><\/strong>, un membre du R\u00e9seau MRM \u00e9crit sur les cellules souches et la m\u00e9decine r\u00e9g\u00e9n\u00e9rative d\u2019un point de vue diff\u00e9rent. Ce mois-ci, le Dr Vahab Soleimani<\/strong>, Professeur agr\u00e9g\u00e9 au D\u00e9partement de g\u00e9n\u00e9tique humaine de McGill et chercheur \u00e0 l’Institut Lady Davis, et Darren Blackburn<\/strong>, candidat au doctorat dans son laboratoire, nous parlent du rajeunissement transcriptionnel de cellules souches musculaires ag\u00e9es.<\/strong><\/p>\n

Rajeunissement transcriptionnel de cellules souches musculaires \u00e2g\u00e9es par un environnement de niche jeune<\/h2>\n

Le muscle squelettique sain a une puissante capacit\u00e9 de r\u00e9g\u00e9n\u00e9ration en raison de la pr\u00e9sence d\u2019une petite population de cellules souches musculaires (MuSC) qui assurent le maintien et la r\u00e9paration \u00e0 vie du tissu. Les MuSC, comme les autres cellules dans le corps, n\u2019existent pas dans le vide; Leur sant\u00e9 et leur fonction sont dict\u00e9es non seulement par leurs propri\u00e9t\u00e9s intrins\u00e8ques, mais aussi par les interactions qu\u2019elles ont avec leur environnement de niche. L\u2019environnement de niche dans lequel r\u00e9sident les MuSC joue un r\u00f4le essentiel dans leur fonction. La niche englobe de nombreuses cellules non myog\u00e9niques telles que les prog\u00e9niteurs fibro-adipog\u00e9niques (FAP), les macrophages, les cellules endoth\u00e9liales et les fibroblastes, entre autres, qui se sont r\u00e9v\u00e9l\u00e9s importants dans la r\u00e9gulation de la quiescence, de la prolif\u00e9ration et de la diff\u00e9renciation des MuSC1-4<\/sup>. En plus des cellules r\u00e9sidentes, l\u2019environnement de niche est \u00e9galement affect\u00e9 par des facteurs syst\u00e9miques provenant de la circulation sanguine ainsi que des composants structurels tels que les myofibres et la composition de la matrice extracellulaire (MEC)5-8<\/sup>.<\/p>\n

Le vieillissement a un effet n\u00e9gatif consid\u00e9rable sur les muscles squelettiques et, par cons\u00e9quent, sur l\u2019environnement de niche des MuSC en raison de l\u2019augmentation de l\u2019inflammation, de la fibrose, de l\u2019infiltration de graisse et de l\u2019atrophie musculaire qui appara\u00eessent lors du vieillisement. Ces alt\u00e9rations dans le muscle perturbent la diaphonie entre les MuSC et les cellules voisines, conduisant \u00e0 une rupture du soutien des MuSC par la niche9-11<\/sup>. Historiquement, les exp\u00e9riences de parabiose ont montr\u00e9 que l\u2019exposition de muscles \u00e2g\u00e9s \u00e0 de jeunes facteurs circulatoires peut restaurer la capacit\u00e9 de r\u00e9g\u00e9n\u00e9ration des muscles \u00e2g\u00e9s12<\/sup>, d\u00e9montrant l\u2019effet que les facteurs extrins\u00e8ques peuvent avoir sur la fonction des MuSC.<\/p>\n

\"\"

Figure 1: <\/strong> Sch\u00e9ma du mod\u00e8le de transplantation utilis\u00e9 dans l\u2019\u00e9tude. Cr\u00e9\u00e9 avec Biorender.com<\/p><\/div>\n

Dans une \u00e9tude r\u00e9cente, nous avons adopt\u00e9 une approche \u00e0 plusieurs volets utilisant la g\u00e9nomique unicellulaire et avons analys\u00e9 l\u2019effet du vieillissement sur la dynamique de la population, l\u2019\u00e9pig\u00e9nome et le transcriptome des MuSC13<\/sup>. L\u2019analyse des donn\u00e9es scRNA-seq a montr\u00e9 que la perte de cellules souches musculaires li\u00e9e \u00e0 l\u2019\u00e2ge n\u2019est pas al\u00e9atoire et que des sous-populations sp\u00e9cifiques sont pr\u00e9f\u00e9rentiellement perdues chez les souris \u00e2g\u00e9es. Fait int\u00e9ressant, les sous-populations qui sont retenues chez les souris \u00e2g\u00e9es augmentent l\u2019expression de la r\u00e9ponse au stress et des g\u00e8nes antioxydants. Cette d\u00e9couverte sugg\u00e8re que l\u2019activation des g\u00e8nes antioxydants et de r\u00e9ponse au stress peut permettre \u00e0 ces cellules de survivre dans un environnement musculaire \u00e2g\u00e9.<\/p>\n

Pour d\u00e9terminer si l\u2019expression g\u00e9nique alt\u00e9r\u00e9e par l\u2019\u00e2ge est r\u00e9versible, nous avons con\u00e7u un mod\u00e8le de greffe de cellules souches musculaires in vivo<\/em> dans lequel nous avons isol\u00e9 des MuSC marqu\u00e9es GFP chez d\u2019anciens donneurs et les avons transplant\u00e9es dans le muscle squelettique de jeunes souris h\u00f4tes13<\/sup>. Les MuSC greff\u00e9es ont eu trois semaines rejoindre la niche et se remettre \u00e0 l’\u00e9tat de quiescence. Les cellules greff\u00e9es ont \u00e9t\u00e9 ensuite isol\u00e9es \u00e0 nouveau et leur transcriptome entier a \u00e9t\u00e9 analys\u00e9 par RNA-seq. Il est frappant de constater qu\u2019environ la moiti\u00e9 des g\u00e8nes modifi\u00e9s par l\u2019\u00e2ge ont \u00e9t\u00e9 restaur\u00e9s (rajeunis transcriptionnellement) \u00e0 la suite d\u2019une exposition \u00e0 un environnement de niche jeune. La r\u00e9versibilit\u00e9 du transcriptome des MuSC sugg\u00e8re que le ciblage de l\u2019environnement de niche peut \u00eatre une future avenue th\u00e9rapeutique importante pour restaurer la r\u00e9paration musculaire endog\u00e8ne m\u00e9di\u00e9e par les cellules souches dans le vieillissement et d\u2019autres conditions de fonte musculaire.<\/p>\n

Bien que cette \u00e9tude fournisse un nouvel aper\u00e7u critique du r\u00f4le de l\u2019environnement de niche dans la r\u00e9gulation de l\u2019expression des g\u00e8nes des MuSC, de nombreuses questions fondamentales restent sans r\u00e9ponse. Par exemple, quels facteurs dans l\u2019environnement de niche jeune agissent comme des \u00e9l\u00e9ments rajeunissants ? De plus, le vieillissement entra\u00eene \u00e9galement une alt\u00e9ration significative de l\u2019accessibilit\u00e9 de la chromatine et de la m\u00e9thylation de l\u2019ADN; La jeune niche \u00e9pig\u00e9n\u00e9tiquement peut-elle rajeunir les MuSC \u00e2g\u00e9es ? En d\u2019autres termes, les alt\u00e9rations de la chromatine li\u00e9es \u00e0 l\u2019\u00e2ge peuvent-elles \u00eatre restaur\u00e9es par une exposition \u00e0 la niche ? En outre, l\u2019extension de cette analyse aux cellules non myog\u00e9niques du muscle squelettique pour \u00e9tudier leur rajeunissement transcriptionnel potentiel par un environnement de niche jeune peut identifier des facteurs communs ou des voies biologiques qui peuvent \u00eatre utilis\u00e9s comme cibles mol\u00e9culaires pour am\u00e9liorer la r\u00e9g\u00e9n\u00e9ration musculaire.<\/p>\n

Pour en savoir plus sur ce sujet, consultez l\u2019article r\u00e9cemment publi\u00e9 par le Laboratoire Soleimani et leurs collaborateurs dans Nature Comms:<\/strong> Transcriptional reprogramming of skeletal muscle stem cells by the niche environment<\/a>.<\/em><\/p>\n

 <\/p>\n

R\u00e9f\u00e9rences<\/em><\/h3>\n

1 Biferali, B., Proietti, D., Mozzetta, C. & Madaro, L. Fibro\u2013Adipogenic Progenitors Cross-Talk in Skeletal Muscle: The Social Network. Frontiers in Physiology<\/em> 10<\/strong> (2019). https:\/\/doi.org:10.3389\/fphys.2019.01074<\/a>
\n2 Joe, A. W. et al.<\/em> Muscle injury activates resident fibro\/adipogenic progenitors that facilitate myogenesis. Nat Cell Biol<\/em> 12<\/strong>, 153-163 (2010). https:\/\/doi.org:10.1038\/ncb2015<\/a>
\n3 Verma, M. et al.<\/em> Muscle Satellite Cell Cross-Talk with a Vascular Niche Maintains Quiescence via VEGF and Notch Signaling. Cell Stem Cell<\/em> 23<\/strong>, 530-543 e539 (2018). https:\/\/doi.org:10.1016\/j.stem.2018.09.007<\/a>
\n4 Ratnayake, D. et al. Macrophages provide a transient muscle stem cell niche via NAMPT secretion. Nature 591<\/strong>, 281-287 (2021). https:\/\/doi.org:10.1038\/s41586-021-03199-7<\/a>
\n5 Li, H. et al.<\/em> Muscle-secreted granulocyte colony-stimulating factor functions as metabolic niche factor ameliorating loss of muscle stem cells in aged mice. The EMBO Journal<\/em> 38<\/strong>, e102154 (2019). https:\/\/doi.org:10.15252\/embj.2019102154<\/a>
\n6 Gilbert, P. M. et al. Substrate elasticity regulates skeletal muscle stem cell self-renewal in culture. Science<\/em> 329<\/strong>, 1078-1081 (2010). https:\/\/doi.org:10.1126\/science.1191035<\/a>
\n7 Garg, K. & Boppart, M. D. Influence of exercise and aging on extracellular matrix composition in the skeletal muscle stem cell niche. J Appl Physiol<\/em> (1985) 121<\/strong>, 1053-1058 (2016). https:\/\/doi.org:10.1152\/japplphysiol.00594.2016<\/a>
\n8 Oh, J. et al.<\/em> Age-associated NF-\u03baB signaling in myofibers alters the satellite cell niche and re-strains muscle stem cell function. Aging (Albany NY)<\/em> 8<\/strong>, 2871-2896 (2016). https:\/\/doi.org:10.18632\/aging.101098<\/a>
\n9 Ancel, S., Mashinchian, O. & Feige, J. N. Adipogenic progenitors keep muscle stem cells young. Aging<\/em> 11<\/strong>, 7331-7333 (2019). https:\/\/doi.org:10.18632\/aging.102304<\/a>
\n10 Lukjanenko, L. et al.<\/em> Aging Disrupts Muscle Stem Cell Function by Impairing Matricellular WISP1 Secretion from Fibro-Adipogenic Progenitors. Cell Stem Cell<\/em> 24<\/strong>, 433-446.e437 (2019). https:\/\/doi.org:https:\/\/doi.org\/10.1016\/j.stem.2018.12.014<\/a>
\n11 Lukjanenko, L. et al.<\/em> Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice. Nat Med<\/em> 22<\/strong>, 897-905 (2016). https:\/\/doi.org:10.1038\/nm.4126<\/a>
\n12 Conboy, I. M. et al.<\/em> Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature<\/em> 433<\/strong>, 760-764 (2005). https:\/\/doi.org:10.1038\/nature03260<\/a>
\n13 Lazure, F. et al.<\/em> Transcriptional reprogramming of skeletal muscle stem cells by the niche environment. Nat Commun<\/em> 14<\/strong>, 535 (2023). https:\/\/doi.org:10.1038\/s41467-023-36265-x<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Chaque mois, dans les\u00a0MRM Insights, un membre du R\u00e9seau MRM \u00e9crit sur les cellules souches…<\/p>\n","protected":false},"author":6,"featured_media":9807,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"ngg_post_thumbnail":0,"footnotes":""},"categories":[162],"tags":[335,164,178,359,402,686,683],"class_list":["post-9835","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-mrm-insights-fr","tag-cellules-souches-musculaires","tag-mrm-fr","tag-mrm-insights-fr","tag-muscle-stem-cells-fr","tag-niche","tag-rajeunissement","tag-rejuvenation-fr"],"acf":[],"yoast_head":"\nMRM Insights: Rajeunissement transcriptionnel de cellules souches musculaires \u00e2g\u00e9es | MRM<\/title>\n<meta name=\"description\" content=\"Chaque mois, dans MRM Insights, un membre du R\u00e9seau MRM \u00e9crit sur les cellules souches et la m\u00e9decine r\u00e9g\u00e9n\u00e9rative d\u2019un point de vue diff\u00e9rent\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mrm.research.mcgill.ca\/fr\/2023\/04\/mrm-insights-rajeunissement-transcriptionnel-de-cellules-souches-musculaires-agees\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"MRM Insights: Rajeunissement transcriptionnel de cellules souches musculaires \u00e2g\u00e9es | MRM\" \/>\n<meta property=\"og:description\" content=\"Chaque mois, dans MRM Insights, un membre du R\u00e9seau MRM \u00e9crit sur les cellules souches et la m\u00e9decine r\u00e9g\u00e9n\u00e9rative d\u2019un point de vue diff\u00e9rent\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mrm.research.mcgill.ca\/fr\/2023\/04\/mrm-insights-rajeunissement-transcriptionnel-de-cellules-souches-musculaires-agees\/\" \/>\n<meta property=\"og:site_name\" content=\"MRM\" \/>\n<meta property=\"article:published_time\" content=\"2023-04-03T13:15:50+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-04-04T19:25:42+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mrm.research.mcgill.ca\/wp-content\/uploads\/2023\/03\/MRM-Insights_2023-04_News.png\" \/>\n\t<meta property=\"og:image:width\" content=\"900\" \/>\n\t<meta property=\"og:image:height\" content=\"510\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Marine Christin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@MRM_Network\" \/>\n<meta name=\"twitter:site\" content=\"@MRM_Network\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"Marine Christin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/mrm.research.mcgill.ca\/fr\/2023\/04\/mrm-insights-rajeunissement-transcriptionnel-de-cellules-souches-musculaires-agees\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/mrm.research.mcgill.ca\/fr\/2023\/04\/mrm-insights-rajeunissement-transcriptionnel-de-cellules-souches-musculaires-agees\/\"},\"author\":{\"name\":\"Marine Christin\",\"@id\":\"https:\/\/mrm.research.mcgill.ca\/fr\/#\/schema\/person\/e5f359d07157e991dc193530c8fa4738\"},\"headline\":\"MRM Insights: Rajeunissement transcriptionnel de cellules souches musculaires \u00e2g\u00e9es\",\"datePublished\":\"2023-04-03T13:15:50+00:00\",\"dateModified\":\"2023-04-04T19:25:42+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/mrm.research.mcgill.ca\/fr\/2023\/04\/mrm-insights-rajeunissement-transcriptionnel-de-cellules-souches-musculaires-agees\/\"},\"wordCount\":1325,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/mrm.research.mcgill.ca\/fr\/#organization\"},\"image\":{\"@id\":\"https:\/\/mrm.research.mcgill.ca\/fr\/2023\/04\/mrm-insights-rajeunissement-transcriptionnel-de-cellules-souches-musculaires-agees\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/mrm.research.mcgill.ca\/wp-content\/uploads\/2023\/03\/MRM-Insights_2023-04_News.png\",\"keywords\":[\"Cellules souches musculaires\",\"MRM\",\"MRM Insights\",\"muscle stem cells\",\"niche\",\"rajeunissement\",\"rejuvenation\"],\"articleSection\":[\"MRM Insights\"],\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/mrm.research.mcgill.ca\/fr\/2023\/04\/mrm-insights-rajeunissement-transcriptionnel-de-cellules-souches-musculaires-agees\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/mrm.research.mcgill.ca\/fr\/2023\/04\/mrm-insights-rajeunissement-transcriptionnel-de-cellules-souches-musculaires-agees\/\",\"url\":\"https:\/\/mrm.research.mcgill.ca\/fr\/2023\/04\/mrm-insights-rajeunissement-transcriptionnel-de-cellules-souches-musculaires-agees\/\",\"name\":\"MRM Insights: Rajeunissement transcriptionnel de cellules souches musculaires \u00e2g\u00e9es | MRM\",\"isPartOf\":{\"@id\":\"https:\/\/mrm.research.mcgill.ca\/fr\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/mrm.research.mcgill.ca\/fr\/2023\/04\/mrm-insights-rajeunissement-transcriptionnel-de-cellules-souches-musculaires-agees\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/mrm.research.mcgill.ca\/fr\/2023\/04\/mrm-insights-rajeunissement-transcriptionnel-de-cellules-souches-musculaires-agees\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/mrm.research.mcgill.ca\/wp-content\/uploads\/2023\/03\/MRM-Insights_2023-04_News.png\",\"datePublished\":\"2023-04-03T13:15:50+00:00\",\"dateModified\":\"2023-04-04T19:25:42+00:00\",\"description\":\"Chaque mois, dans MRM Insights, un membre du R\u00e9seau MRM \u00e9crit sur les cellules souches et la m\u00e9decine r\u00e9g\u00e9n\u00e9rative d\u2019un point de vue diff\u00e9rent\",\"breadcrumb\":{\"@id\":\"https:\/\/mrm.research.mcgill.ca\/fr\/2023\/04\/mrm-insights-rajeunissement-transcriptionnel-de-cellules-souches-musculaires-agees\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/mrm.research.mcgill.ca\/fr\/2023\/04\/mrm-insights-rajeunissement-transcriptionnel-de-cellules-souches-musculaires-agees\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/mrm.research.mcgill.ca\/fr\/2023\/04\/mrm-insights-rajeunissement-transcriptionnel-de-cellules-souches-musculaires-agees\/#primaryimage\",\"url\":\"https:\/\/mrm.research.mcgill.ca\/wp-content\/uploads\/2023\/03\/MRM-Insights_2023-04_News.png\",\"contentUrl\":\"https:\/\/mrm.research.mcgill.ca\/wp-content\/uploads\/2023\/03\/MRM-Insights_2023-04_News.png\",\"width\":900,\"height\":510},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/mrm.research.mcgill.ca\/fr\/2023\/04\/mrm-insights-rajeunissement-transcriptionnel-de-cellules-souches-musculaires-agees\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/mrm.research.mcgill.ca\/fr\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"MRM Insights: Rajeunissement transcriptionnel de cellules souches musculaires \u00e2g\u00e9es\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/mrm.research.mcgill.ca\/fr\/#website\",\"url\":\"https:\/\/mrm.research.mcgill.ca\/fr\/\",\"name\":\"MRM\",\"description\":\"R\u00e9seau de M\u00e9decine R\u00e9g\u00e9n\u00e9rative de McGill\",\"publisher\":{\"@id\":\"https:\/\/mrm.research.mcgill.ca\/fr\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/mrm.research.mcgill.ca\/fr\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/mrm.research.mcgill.ca\/fr\/#organization\",\"name\":\"McGill Regenerative Medicine Network\",\"url\":\"https:\/\/mrm.research.mcgill.ca\/fr\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/mrm.research.mcgill.ca\/fr\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/mrm.research.mcgill.ca\/wp-content\/uploads\/2019\/07\/McGill_MRM_logo_bil_FINAL.png\",\"contentUrl\":\"https:\/\/mrm.research.mcgill.ca\/wp-content\/uploads\/2019\/07\/McGill_MRM_logo_bil_FINAL.png\",\"width\":1407,\"height\":216,\"caption\":\"McGill Regenerative Medicine Network\"},\"image\":{\"@id\":\"https:\/\/mrm.research.mcgill.ca\/fr\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/x.com\/MRM_Network\",\"https:\/\/www.linkedin.com\/company\/mrm-network\/\",\"https:\/\/www.youtube.com\/channel\/UCaAGbCSI_6mWCVSydBHc2-g\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/mrm.research.mcgill.ca\/fr\/#\/schema\/person\/e5f359d07157e991dc193530c8fa4738\",\"name\":\"Marine Christin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/mrm.research.mcgill.ca\/fr\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/891e0ea3b86d515cd9f0a350756668ce?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/891e0ea3b86d515cd9f0a350756668ce?s=96&d=mm&r=g\",\"caption\":\"Marine Christin\"},\"url\":\"https:\/\/mrm.research.mcgill.ca\/fr\/author\/marine\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"MRM Insights: Rajeunissement transcriptionnel de cellules souches musculaires \u00e2g\u00e9es | MRM","description":"Chaque mois, dans MRM Insights, un membre du R\u00e9seau MRM \u00e9crit sur les cellules souches et la m\u00e9decine r\u00e9g\u00e9n\u00e9rative d\u2019un point de vue diff\u00e9rent","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/mrm.research.mcgill.ca\/fr\/2023\/04\/mrm-insights-rajeunissement-transcriptionnel-de-cellules-souches-musculaires-agees\/","og_locale":"fr_FR","og_type":"article","og_title":"MRM Insights: Rajeunissement transcriptionnel de cellules souches musculaires \u00e2g\u00e9es | MRM","og_description":"Chaque mois, dans MRM Insights, un membre du R\u00e9seau MRM \u00e9crit sur les cellules souches et la m\u00e9decine r\u00e9g\u00e9n\u00e9rative d\u2019un point de vue diff\u00e9rent","og_url":"https:\/\/mrm.research.mcgill.ca\/fr\/2023\/04\/mrm-insights-rajeunissement-transcriptionnel-de-cellules-souches-musculaires-agees\/","og_site_name":"MRM","article_published_time":"2023-04-03T13:15:50+00:00","article_modified_time":"2023-04-04T19:25:42+00:00","og_image":[{"width":900,"height":510,"url":"https:\/\/mrm.research.mcgill.ca\/wp-content\/uploads\/2023\/03\/MRM-Insights_2023-04_News.png","type":"image\/png"}],"author":"Marine Christin","twitter_card":"summary_large_image","twitter_creator":"@MRM_Network","twitter_site":"@MRM_Network","twitter_misc":{"\u00c9crit par":"Marine Christin","Dur\u00e9e de lecture estim\u00e9e":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/mrm.research.mcgill.ca\/fr\/2023\/04\/mrm-insights-rajeunissement-transcriptionnel-de-cellules-souches-musculaires-agees\/#article","isPartOf":{"@id":"https:\/\/mrm.research.mcgill.ca\/fr\/2023\/04\/mrm-insights-rajeunissement-transcriptionnel-de-cellules-souches-musculaires-agees\/"},"author":{"name":"Marine Christin","@id":"https:\/\/mrm.research.mcgill.ca\/fr\/#\/schema\/person\/e5f359d07157e991dc193530c8fa4738"},"headline":"MRM Insights: Rajeunissement transcriptionnel de cellules souches musculaires \u00e2g\u00e9es","datePublished":"2023-04-03T13:15:50+00:00","dateModified":"2023-04-04T19:25:42+00:00","mainEntityOfPage":{"@id":"https:\/\/mrm.research.mcgill.ca\/fr\/2023\/04\/mrm-insights-rajeunissement-transcriptionnel-de-cellules-souches-musculaires-agees\/"},"wordCount":1325,"commentCount":0,"publisher":{"@id":"https:\/\/mrm.research.mcgill.ca\/fr\/#organization"},"image":{"@id":"https:\/\/mrm.research.mcgill.ca\/fr\/2023\/04\/mrm-insights-rajeunissement-transcriptionnel-de-cellules-souches-musculaires-agees\/#primaryimage"},"thumbnailUrl":"https:\/\/mrm.research.mcgill.ca\/wp-content\/uploads\/2023\/03\/MRM-Insights_2023-04_News.png","keywords":["Cellules souches musculaires","MRM","MRM Insights","muscle stem cells","niche","rajeunissement","rejuvenation"],"articleSection":["MRM Insights"],"inLanguage":"fr-FR","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/mrm.research.mcgill.ca\/fr\/2023\/04\/mrm-insights-rajeunissement-transcriptionnel-de-cellules-souches-musculaires-agees\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/mrm.research.mcgill.ca\/fr\/2023\/04\/mrm-insights-rajeunissement-transcriptionnel-de-cellules-souches-musculaires-agees\/","url":"https:\/\/mrm.research.mcgill.ca\/fr\/2023\/04\/mrm-insights-rajeunissement-transcriptionnel-de-cellules-souches-musculaires-agees\/","name":"MRM Insights: Rajeunissement transcriptionnel de cellules souches musculaires \u00e2g\u00e9es | MRM","isPartOf":{"@id":"https:\/\/mrm.research.mcgill.ca\/fr\/#website"},"primaryImageOfPage":{"@id":"https:\/\/mrm.research.mcgill.ca\/fr\/2023\/04\/mrm-insights-rajeunissement-transcriptionnel-de-cellules-souches-musculaires-agees\/#primaryimage"},"image":{"@id":"https:\/\/mrm.research.mcgill.ca\/fr\/2023\/04\/mrm-insights-rajeunissement-transcriptionnel-de-cellules-souches-musculaires-agees\/#primaryimage"},"thumbnailUrl":"https:\/\/mrm.research.mcgill.ca\/wp-content\/uploads\/2023\/03\/MRM-Insights_2023-04_News.png","datePublished":"2023-04-03T13:15:50+00:00","dateModified":"2023-04-04T19:25:42+00:00","description":"Chaque mois, dans MRM Insights, un membre du R\u00e9seau MRM \u00e9crit sur les cellules souches et la m\u00e9decine r\u00e9g\u00e9n\u00e9rative d\u2019un point de vue diff\u00e9rent","breadcrumb":{"@id":"https:\/\/mrm.research.mcgill.ca\/fr\/2023\/04\/mrm-insights-rajeunissement-transcriptionnel-de-cellules-souches-musculaires-agees\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/mrm.research.mcgill.ca\/fr\/2023\/04\/mrm-insights-rajeunissement-transcriptionnel-de-cellules-souches-musculaires-agees\/"]}]},{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/mrm.research.mcgill.ca\/fr\/2023\/04\/mrm-insights-rajeunissement-transcriptionnel-de-cellules-souches-musculaires-agees\/#primaryimage","url":"https:\/\/mrm.research.mcgill.ca\/wp-content\/uploads\/2023\/03\/MRM-Insights_2023-04_News.png","contentUrl":"https:\/\/mrm.research.mcgill.ca\/wp-content\/uploads\/2023\/03\/MRM-Insights_2023-04_News.png","width":900,"height":510},{"@type":"BreadcrumbList","@id":"https:\/\/mrm.research.mcgill.ca\/fr\/2023\/04\/mrm-insights-rajeunissement-transcriptionnel-de-cellules-souches-musculaires-agees\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/mrm.research.mcgill.ca\/fr\/"},{"@type":"ListItem","position":2,"name":"MRM Insights: Rajeunissement transcriptionnel de cellules souches musculaires \u00e2g\u00e9es"}]},{"@type":"WebSite","@id":"https:\/\/mrm.research.mcgill.ca\/fr\/#website","url":"https:\/\/mrm.research.mcgill.ca\/fr\/","name":"MRM","description":"R\u00e9seau de M\u00e9decine R\u00e9g\u00e9n\u00e9rative de McGill","publisher":{"@id":"https:\/\/mrm.research.mcgill.ca\/fr\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/mrm.research.mcgill.ca\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"},{"@type":"Organization","@id":"https:\/\/mrm.research.mcgill.ca\/fr\/#organization","name":"McGill Regenerative Medicine Network","url":"https:\/\/mrm.research.mcgill.ca\/fr\/","logo":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/mrm.research.mcgill.ca\/fr\/#\/schema\/logo\/image\/","url":"https:\/\/mrm.research.mcgill.ca\/wp-content\/uploads\/2019\/07\/McGill_MRM_logo_bil_FINAL.png","contentUrl":"https:\/\/mrm.research.mcgill.ca\/wp-content\/uploads\/2019\/07\/McGill_MRM_logo_bil_FINAL.png","width":1407,"height":216,"caption":"McGill Regenerative Medicine Network"},"image":{"@id":"https:\/\/mrm.research.mcgill.ca\/fr\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/x.com\/MRM_Network","https:\/\/www.linkedin.com\/company\/mrm-network\/","https:\/\/www.youtube.com\/channel\/UCaAGbCSI_6mWCVSydBHc2-g"]},{"@type":"Person","@id":"https:\/\/mrm.research.mcgill.ca\/fr\/#\/schema\/person\/e5f359d07157e991dc193530c8fa4738","name":"Marine Christin","image":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/mrm.research.mcgill.ca\/fr\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/891e0ea3b86d515cd9f0a350756668ce?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/891e0ea3b86d515cd9f0a350756668ce?s=96&d=mm&r=g","caption":"Marine Christin"},"url":"https:\/\/mrm.research.mcgill.ca\/fr\/author\/marine\/"}]}},"_links":{"self":[{"href":"https:\/\/mrm.research.mcgill.ca\/fr\/wp-json\/wp\/v2\/posts\/9835","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mrm.research.mcgill.ca\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mrm.research.mcgill.ca\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mrm.research.mcgill.ca\/fr\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/mrm.research.mcgill.ca\/fr\/wp-json\/wp\/v2\/comments?post=9835"}],"version-history":[{"count":7,"href":"https:\/\/mrm.research.mcgill.ca\/fr\/wp-json\/wp\/v2\/posts\/9835\/revisions"}],"predecessor-version":[{"id":9888,"href":"https:\/\/mrm.research.mcgill.ca\/fr\/wp-json\/wp\/v2\/posts\/9835\/revisions\/9888"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mrm.research.mcgill.ca\/fr\/wp-json\/wp\/v2\/media\/9807"}],"wp:attachment":[{"href":"https:\/\/mrm.research.mcgill.ca\/fr\/wp-json\/wp\/v2\/media?parent=9835"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mrm.research.mcgill.ca\/fr\/wp-json\/wp\/v2\/categories?post=9835"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mrm.research.mcgill.ca\/fr\/wp-json\/wp\/v2\/tags?post=9835"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}