{"id":7175,"date":"2021-11-25T11:19:30","date_gmt":"2021-11-25T16:19:30","guid":{"rendered":"https:\/\/mrm.research.mcgill.ca\/event\/2022-mrm-talks-dr-terry-hebert-and-kyla-bourque\/"},"modified":"2023-03-08T10:10:09","modified_gmt":"2023-03-08T15:10:09","slug":"mrm-talks-2022-dr-terry-hebert-et-kyla-bourque","status":"publish","type":"scrm_events","link":"https:\/\/mrm.research.mcgill.ca\/fr\/event\/mrm-talks-2022-dr-terry-hebert-et-kyla-bourque\/","title":{"rendered":"MRM Talks 2022 : Dr Terry H\u00e9bert et Kyla Bourque"},"content":{"rendered":"<p>Le R\u00e9seau MRM pr\u00e9sente : les <a href=\"https:\/\/mrm.research.mcgill.ca\/fr\/notre-reseau\/mrm-talks\/\">MRM Talks<\/a>. Rejoignez-nous <strong>chaque quatri\u00e8me jeudi du mois \u00e0 midi<\/strong> pour en apprendre plus sur les cellules souches et la m\u00e9decine r\u00e9g\u00e9n\u00e9rative. La s\u00e9rie de webinaires mettra en vedette d\u2019\u00e9minents scientifiques du domaine, incluant des chercheurs du MRM et des conf\u00e9renciers invit\u00e9s.<\/p>\n<p>Pour chaque webinaire, nous mettrons \u00e9galement en avant le travail d\u2019un(e) <strong>\u00e9tudiant(e) du MRM<\/strong> qui pr\u00e9sentera aux c\u00f4t\u00e9s du conf\u00e9rencier principal.<\/p>\n<h2 style=\"text-align: left;\">Dans cette \u00e9dition des MRM Talks :<\/h2>\n<p><strong><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-7151 alignleft\" src=\"https:\/\/mrm.research.mcgill.ca\/wp-content\/uploads\/2021\/11\/Terry-Hebert_MRM-Talks.jpg\" alt=\"\" width=\"115\" height=\"139\" srcset=\"https:\/\/mrm.research.mcgill.ca\/wp-content\/uploads\/2021\/11\/Terry-Hebert_MRM-Talks.jpg 330w, https:\/\/mrm.research.mcgill.ca\/wp-content\/uploads\/2021\/11\/Terry-Hebert_MRM-Talks-248x300.jpg 248w\" sizes=\"auto, (max-width: 115px) 100vw, 115px\" \/>Dr. Terry H\u00e9bert,<br \/>\n<\/strong>Professeur et Directeur du programme d&rsquo;\u00e9tudes sup\u00e9rieures, D\u00e9partement de pharmacologie et th\u00e9rapeutiques<br \/>\nTitulaire d&rsquo;une chaire de recherche Canadian Pacific en biotechnologies<br \/>\nDoyen adjoint, \u00c9ducation sciences biom\u00e9dicales, Universit\u00e9 McGill<br \/>\nDirecteur, R\u00e9seau MRM<\/p>\n<p><em><strong>\u201cUsing iPSCs to track disease evolution and therapeutic responses one cell at a time\u201d<\/strong><\/em><\/p>\n<h5>\u00c9TUDIANTE MRM :<\/h5>\n<p><strong><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-7159 alignleft\" src=\"https:\/\/mrm.research.mcgill.ca\/wp-content\/uploads\/2021\/11\/Kyla-Bourque_MRM-Talks.jpg\" alt=\"\" width=\"115\" height=\"139\" srcset=\"https:\/\/mrm.research.mcgill.ca\/wp-content\/uploads\/2021\/11\/Kyla-Bourque_MRM-Talks.jpg 330w, https:\/\/mrm.research.mcgill.ca\/wp-content\/uploads\/2021\/11\/Kyla-Bourque_MRM-Talks-248x300.jpg 248w\" sizes=\"auto, (max-width: 115px) 100vw, 115px\" \/>Kyla Bourque,<br \/>\n<\/strong>Candidate au doctorat dans le laboratoire du Pr Terry H\u00e9bert<br \/>\nUniversit\u00e9 McGill<strong><br \/>\n<\/strong><\/p>\n<p><em><strong>\u201cSingle-cell profiling of signalling networks in primary neonatal cardiomyocytes and iPSC-CMs\u201d<\/strong><\/em><\/p>\n<p>&nbsp;<\/p>\n<h5>JEUDI 27 Janvier 2022<br \/>\n12h \u2013 13h<br \/>\nVIRTUEL<\/h5>\n<p>Vous avez manqu\u00e9 la pr\u00e9sentation ? Vous pouvez la revoir sur notre\u00a0<a href=\"https:\/\/youtu.be\/zGG1ezSRNjI\" target=\"_blank\" rel=\"noopener\">Cha\u00eene Youtube<\/a>.<\/p>\n<p><iframe loading=\"lazy\" title=\"2022 MRM Talks - Dr. Terry H\u00e9bert\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/zGG1ezSRNjI?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p>&nbsp;<\/p>\n<h3>\u00c0 propos des conf\u00e9renciers :<\/h3>\n<p>Le <strong>Dr Terry H\u00e9bert<\/strong> a une longue exp\u00e9rience dans la compr\u00e9hension de la biologie des RCPG et des prot\u00e9ines G, en mettant l\u2019accent sur l\u2019oligom\u00e9risation, l\u2019assemblage complexe de signalisation et la localisation au noyau. Ses recherches actuelles portent sur l\u2019ontogen\u00e8se, la formation et le trafic de complexes de signalisation GPCR pour comprendre l\u2019architecture, le c\u00e2blage et l\u2019int\u00e9gration des voies de signalisation GPCR individuelles \u00e0 la surface de la cellule et du noyau. Son travail a eu de multiples impacts : tout d\u2019abord, ses recherches fondamentales ont fait progresser notre compr\u00e9hension de l\u2019assemblage des complexes de signalisation GPCR, de la pr\u00e9sence et de la fonction de tels complexes sur la membrane nucl\u00e9aire et des r\u00f4les enti\u00e8rement nouveaux pour les prot\u00e9ines G en tant que r\u00e9gulateurs transcriptionnels. Deuxi\u00e8mement, une piste innovante a men\u00e9 au d\u00e9veloppement de nombreux nouveaux biocapteurs qui captent les signalosomes des RCPG dans diff\u00e9rents contextes. Cela a \u00e9galement permis le d\u00e9veloppement d\u2019un deuxi\u00e8me type de biocapteur qui suit la conformation des RCPG, ce qui est unique \u00e0 son laboratoire. Enfin, une piste de traduction clinique a \u00e9merg\u00e9, incluant des travaux collaboratifs sur le d\u00e9veloppement de modulateurs allost\u00e9riques biais\u00e9s pour le r\u00e9cepteur PGF2\u03b1 afin de retarder le travail pr\u00e9matur\u00e9 chez la femme enceinte et le test des dim\u00e8res GPCR comme cibles th\u00e9rapeutiques dans les maladies cardiovasculaires. <em>Le nouvel accent mis par son laboratoire sur les mutations GNB1, les iPSC et l\u2019utilisation in vivo de leurs biocapteurs a ouvert de nouvelles perspectives productives pour leurs recherches sur les maladies cardiovasculaires, le cancer, les troubles neurod\u00e9veloppementaux et la maladie de Parkinson.<\/em><\/p>\n<p><strong>Kyla Bourque<\/strong> est candidate au doctorat en 6e ann\u00e9e dans le laboratoire du Dr Terry H\u00e9bert. L&rsquo;un aspect de sa th\u00e8se porte sur la comparaison des \u00e9v\u00e9nements de signalisation dans les cardiomyocytes primaires par rapport aux cardiomyocytes d\u00e9riv\u00e9s d\u2019iPSC. Elle s\u2019int\u00e9resse \u00e9galement \u00e0 la compr\u00e9hension de la fa\u00e7on dont les modalit\u00e9s de signalisation changent en cons\u00e9quence de la maladie et elle \u00e9value actuellement cela dans les iPSC-MC d\u00e9riv\u00e9es de patients diagnostiqu\u00e9s avec une cardiomyopathie dilat\u00e9e idiopathique.<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><strong>Nous vous encourageons \u00e0 nous sugg\u00e9rer des conf\u00e9renciers !<\/strong><br \/>\n<strong>Si vous \u00eates int\u00e9ress\u00e9s \u00e0 inviter un scientifique pour une pr\u00e9sentation, <\/strong><a href=\"&#109;&#x61;i&#108;&#x74;o&#58;&#x6d;r&#x6d;&#x40;&#109;&#x63;g&#105;&#x6c;l&#46;&#x63;a\"><strong>contactez-nous<\/strong><\/a><strong>.<\/strong><\/p>\n","protected":false},"featured_media":7165,"template":"","meta":{"_acf_changed":false,"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"ngg_post_thumbnail":0},"class_list":["post-7175","scrm_events","type-scrm_events","status-publish","has-post-thumbnail","hentry","scrm_events_category-mrm-talks-fr","scrm_events_category-seminars-fr"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>MRM Talks 2022 : Dr Terry H\u00e9bert et Kyla Bourque | MRM<\/title>\n<meta name=\"description\" content=\"Les MRM Talks : en savoir plus sur les cellules souches et la 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