{"id":8673,"date":"2022-09-13T11:45:11","date_gmt":"2022-09-13T15:45:11","guid":{"rendered":"https:\/\/mrm.research.mcgill.ca\/event\/manufacturing-gmp-compliant-ipscs-in-closed-and-open-systems\/"},"modified":"2022-09-13T12:03:05","modified_gmt":"2022-09-13T16:03:05","slug":"fabrication-dipsc-conformes-aux-bpf-dans-des-systemes-fermes-et-ouverts","status":"publish","type":"scrm_events","link":"https:\/\/mrm.research.mcgill.ca\/fr\/event\/fabrication-dipsc-conformes-aux-bpf-dans-des-systemes-fermes-et-ouverts\/","title":{"rendered":"Fabrication d\u2019iPSC conformes aux BPF dans des syst\u00e8mes ferm\u00e9s et ouverts"},"content":{"rendered":"<p>Les cellules souches pluripotentes humaines (CSP) et leurs d\u00e9riv\u00e9s ont un grand potentiel dans les th\u00e9rapies cellulaires r\u00e9g\u00e9n\u00e9ratives et ont r\u00e9cemment \u00e9t\u00e9 utilis\u00e9es dans un certain nombre d\u2019essais cliniques ciblant diverses maladies.<\/p>\n<p>Dans ce webinaire, le <strong>Dr Dhruv Sareen<\/strong> (Directeur ex\u00e9cutif, Cedars-Sinai Biomanufacturing Center) pr\u00e9sentera le Cedars-Sinai Biomanufacturing Center, un centre d\u2019excellence de premier plan dans la fabrication de cellules souches pluripotentes induites (iPSC) et de th\u00e9rapies cellulaires et g\u00e9niques. Il d\u00e9crira la fabrication de iPSC humaines dans le cadre des Bonnes Pratiques de Fabrication (BPF) actuelles. Les crit\u00e8res de s\u00e9lection des donneurs, les sources cellulaires, les m\u00e9thodes de reprogrammation, la stabilit\u00e9 g\u00e9n\u00e9tique, les flux de processus de banques de cellules, l\u2019expansion dans les syst\u00e8mes ouverts et ferm\u00e9s, les sp\u00e9cifications et les attributs de qualit\u00e9 critiques connexes seront pris en consid\u00e9ration. Ensuite, le <strong>Dr Chao Sheng<\/strong> (Chef de produit, m\u00e9decine r\u00e9g\u00e9n\u00e9rative, Miltenyi Biotec) pr\u00e9sentera le flux de travail \u00e9tabli par Miltenyi Biotec pour l\u2019expansion de PSC humaines conforme aux BPF \u00e0 l\u2019aide du processus de culture cellulaire adh\u00e9rente CliniMACS Prodigy\u00ae et du milieu GMP iPS-Brew.<\/p>\n<ul>\n<li>S\u2019attaquer aux obstacles majeurs rencontr\u00e9s dans les bioprocessus des iPSCs \u00e0 grande \u00e9chelle et la fabrication de cellules diff\u00e9renci\u00e9es avec les bonnes pratiques de fabrication (BPF) actuelles, en tenant compte de l\u2019impact de la source cellulaire, des m\u00e9thodes de reprogrammation et de l\u2019expansion cellulaire sur la stabilit\u00e9 g\u00e9n\u00e9tique.<\/li>\n<li>D\u00e9velopper des flux de processus efficaces pour les banques iPSC, l\u2019expansion des cellules, les sp\u00e9cifications et les attributs de qualit\u00e9 critiques associ\u00e9s.<\/li>\n<li>Comment r\u00e9aliser une extension PSC conforme aux BPF \u00e0 l\u2019aide du processus CliniMACS Prodigy ferm\u00e9 et automatis\u00e9.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><a href=\"https:\/\/insights.bio\/cell-and-gene-therapy-insights\/webinars\/359\/Manufacturing-GMP-compliant-iPSCs-in-closed-and-open-systems\" class=\"button more\" target=\"_blank\">Inscription<\/a>\n","protected":false},"featured_media":8671,"template":"","meta":{"_acf_changed":false,"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"ngg_post_thumbnail":0},"class_list":["post-8673","scrm_events","type-scrm_events","status-publish","has-post-thumbnail","hentry","scrm_events_category-seminars-fr"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Fabrication d\u2019iPSC conformes aux BPF dans des syst\u00e8mes ferm\u00e9s et ouverts | MRM<\/title>\n<meta name=\"description\" content=\"Webinaire Fabrication d\u2019iPSC conformes aux BPF dans des syst\u00e8mes ferm\u00e9s et ouverts. 180Octobre 18,2022. 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