You can find here the list of Principal Investigators and core facilities managers affiliated to the MRM Network.

If you are a student looking for openings in laboratories within the Network, please check our Looking for a PI section.

Moulay Alaoui-Jamali

Professor
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  • Medicine and Oncology
  • LDI
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Moulay Alaoui-Jamali

Professor

Alaoui-Jamali is Professor in the Departments of Medicine and Oncology at the Faculty of Medicine of McGill University and an associate member of the Departments of Pharmacology and Therapeutics and Rosalind & Morris Goodman Cancer Research Centre. He is also a senior scientist and leader of target/drug discovery team at the Segal Cancer Centre of the Jewish General Hospital.

His research focus encompasses understanding functional diversity and clinical implications of signaling networks that drive cancer progression to metastasis, delineating those that operate on a cancer cell autonomous basis versus those coupled to tumor microenvironment. A particular interest is towards establishing relationships to cancer cell plasticity, dormancy, recurrence, tumor immunosuppressive microenvironment, and response to therapeutics. In addition, his laboratory is actively involved in the discovery of innovative therapeutics capable of targeting invasive cancer cell variants expressing stem cell-like features.

Goffredo Arena

M.D., F.R.C.S, Associate Professor
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  • Surgery and Pathology
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Goffredo Arena

M.D., F.R.C.S, Associate Professor

It is well recognized that the embryonic tissue microenvironment is nonpermissive for tumor development. In my laboratory, we found that conditioned medium derived from human embryonic stem cells has anti-proliferative and pro-apoptotic capabilities towards several cancer cell lines. In addition, this treatment renders these cells less tumorigenic. Understanding this anti-tumorigenic potential and determining the factors involved will provide opportunities to develop new therapeutic tools for cancer treatment.

Geneviève Bernard

M.D., FRCPC, Associate Professor
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  • Neurology and Neurosurgery
  • Human Genetics
  • Pediatrics
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Geneviève Bernard

M.D., FRCPC, Associate Professor

Dr. Geneviève Bernard received her Medical Degree (2002) and Master’s degree in Neurosciences (2003) from Université de Montréal. She completed her residency in Pediatric Neurology at McGill University (2008) and her fellowship in Neurogenetics and Movement Disorders at Université de Montréal (2011) under the supervision of Pr. Bernard Brais, Pr. Guy A Rouleau and Dr. Sylvain Chouinard. She started her career as an independent investigator and pediatric neurologist in October 2011 at the Montreal Children’s Hospital of the McGill University Health Center (MUHC) and MUHC Research Institute. She is the recipient of the Research Scholar Junior 1 salary award from the Fonds de Recherche du Québec en Santé (2012-2016) and the Canadian Institute of Health Research New Investigator salary award (2017-2022). She is currently an Associate Professor at McGill University, in the Departments of Neurology and Neurosurgery, Pediatrics and Human Genetics and a member of the Division of Medical Genetics at the MUHC. Dr. Bernard and her team, together with her international collaborators, discovered the three genes responsible for 4H leukodystrophy, for EPRS-related leukodystrophy, VARS-related neurodegenerative disease and contributed to the discovery of the causal gene for HEMS (Hypomyelination of Early Myelinating structures). Dr. Bernard published, in collaboration with Dr. Nicole Wolf (Amsterdam, The Netherlands) and numerous international collaborators, the largest clinical, radiological and genetic characterization study on 4H leukodystrophy. Dr. Bernard published numerous peer-reviewed publications, including some in high impact factor journals such as Am J Hum Genet, Arch Neurol, Mov Disord, Ann Neurol, Neurology, and Nat Commun, several book chapters and numerous abstracts. She is the Canadian representative on several international consortia, including the Global Leukodystrophy InitiAtive (GLIA).

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Maxime Bouchard

Associate Professor
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  • Biochemistry
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Maxime Bouchard

Associate Professor

Dr. Bouchard is currently Associate Professor at the Goodman Cancer Research Centre and in the Department of Biochemistry. His research covers developmental, adult and cancer stem cells using the mouse as a model system. Dr. Bouchard‘s research program is centered on the cellular mechanisms of cell lineage commitment from stem/progenitor cells. He primarily uses mouse genetics and cellular assays to explore the intrinsic and extrinsic signals driving cellular plasticity during embryo development and in prostate development and cancer.

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Richard Brown

Associate Professor
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  • Obstetrics and Gynecology
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Richard Brown

Associate Professor

Involved in the establishment of the MUHC Stem Cell Clinical Research Cord Blood Bank and served as it’s obstetric director. Collaborated with Dr Laneuville and Dr. L. Peltier in a study evaluating the use of multiple pooled clinical-grade but volume rejected Cord Blood Units for adult stem cell transplantation. My principle interests lie in fetal medicine and fetal therapy and the role of the SCT in the area of fetal structural and genetic malformations offers a vast range of potential conditions that might benefit from such therapies in the future.

Philippe Campeau

Adjunct Professor
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  • Anatomy and Cell Biology
  • UdeM
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Philippe Campeau

Adjunct Professor

Dr. Campeau specialized in medical genetics at McGill and completed a postdoctoral fellowship at the Baylor College of Medicine. He now practices clinical genetics at the Sainte-Justine Hospital and the Shriners Hospital for Children. His research lab studies epilepsy, epigenetic diseases and skeletal dysplasias. They identify disease-causing genes, decipher the pathophysiology, and improve the management of children affected by these conditions.

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Michel Cayouette

Adjunct Professor
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  • Division of Experimental Medicine
  • IRCM
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Michel Cayouette

Adjunct Professor

Michel Cayouette (Ph.D.) is Director of the Cellular Neurobiology Research Unit at the Montreal Clinical Research Institute (IRCM) since 2004. He is also a Full Research Professor in the Department of Medicine at Université de Montréal, and Adjunct Professor in the Department of Anatomy and Cell Biology at McGill University. His research focuses primarily on the cellular and molecular mechanisms regulating neural development and regeneration. Specifically, his lab uncovered a transcriptional cascade regulating how progenitor cells change over time to give rise to specific cell types appropriate for a given developmental stage in the mouse retina. They also discovered key regulators of asymmetric cell divisions in neural progenitors that contribute to the production of cell diversity in the nervous system. In 2017, Dr. Cayouette received the Research Scholar Emeritus award from the Fonds de recherche du Québec – Santé (FRQS) and he holds the IRCM Foundation Gaëtane and Roland Pillenière Chair in Retina Biology. He is Director of the FRQS Vision Health Research Network, Chair of the Scientific Advisory Board of the Foundation Fighting Blindness Canada, Member of the CIHR College of Reviewers, and sits on the Editorial Boards of the journals Neurogenesis (Landes Bioscience), Stem Cells (Wiley-Blackwell), Frontiers in Neuroscience, and acts as section editor for the Journal of Experimental Neuroscience (SAGE Publishing). His research program is funded by a Canadian Institutes of Health Research (CIHR) Foundation grant, the Alzheimer Society, The Foundation Fighting Blindness, and the Brain Canada/Krembil Research Foundations.

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Natasha Chang

Assistant Professor
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  • Biochemistry
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Natasha Chang

Assistant Professor

Dr. Natasha Chang received her Ph.D. in Biochemistry from McGill University, and pursued her postdoctoral fellowship at the Ottawa Hospital Research Institute. Dr. Chang joined McGill as an Assistant Professor in the Department of Biochemistry in 2019. Research in the Chang laboratory focuses on understanding the molecular signalling mechanisms that regulate muscle stem cell function and how these pathways are altered in the context of muscle degenerative disease and muscle cancer. The ultimate goal for Dr. Chang’s research team is to identify molecular targets to improve endogenous stem cell regenerative capacity as well as strategies to improve stem cell transplantation therapy.

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Inés Colmegna

M.D., Associate Professor
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  • Division of Rheumatology
  • RI-MUHC
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Inés Colmegna

M.D., Associate Professor
Division of Rheumatology

My lab research focuses on defining basic mechanisms involved in the disruption of immune tolerance in patients with rheumatoid arthritis (RA). We are specifically interested in understanding the role that adult stem cells have in initiating and perpetuating this disease. Ongoing studies aim to characterize the biology of human hematopoietic and mesenchymal stem cells in patients with recent onset and established RA, the cross talk between stem cells and other immune cells, and the impact that interventions targeting stem cells have on the restoration of immune function.

Colin Crist

Associate Professor
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  • Human Genetics
  • LDI
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Colin Crist

Associate Professor

Dr. Crist’s laboratory at the Lady Davis Institute for Medical Research investigates the molecular biology underlying skeletal muscle development and regeneration. Deepening our understanding of how muscle stem cells develop and function will be key to realizing regenerative medicine based approaches to treating muscle disorders.

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Thomas Durcan

Assistant Professor
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  • Neurology and Neurosurgery
  • MNI
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Thomas Durcan

Assistant Professor

As an assistant professor at the Montreal Neurological Institute (MNI) and McGill University, my research focus is on applying patient-derived stem cells towards the development of phenotypic discovery assays and 3D mini-brain models for both neurodegenerative and neurodevelopmental disorders. As group leader of the iPSC platform at the Montreal Neurological Institute (MNI), I oversee a team of 30 research staff and students and growing, committed to applying novel stem cell technology, combined with CRISPR genome editing, mini-brain models and new microfluidic technologies towards elucidating the underlying causes of these complex disorders. Leading the SGC tissue platform, NeuroSGC; I oversee a team committed to assay development, in parallel with leading the establishment of NeuroCDRD, towards the automation of our open assays for small molecule screens. In addition, I am also part of antibody validation efforts between the MNI, Oxford and the Karolinska to generate CRISPR KO cell-lines for validating commercial antibodies against high-value ALS targets. Combined with new approaches in the group towards building multiomic profiles on the patient-derived IPSC cells within the group, the long-term strategy over the coming years is to identify new personalized precision therapies that can be applied towards building clinical trials on a dish.

Nicoletta Eliopoulos

Assistant Professor
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  • Surgery
  • LDI
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Nicoletta Eliopoulos

Assistant Professor

Dr. Nicoletta Eliopoulos is an Investigator at the Lady Davis Institute for Medical Research (LDI), Jewish General Hospital (JGH), and Assistant Professor in the Department of Surgery, Division of Surgical Research, at McGill University in Montreal. She is also the Laboratory Director of the JGH Cell Processing Center, a clinical-grade cell handling facility which is committed to fostering early-phase trials testing cell-based technologies.
Dr. Eliopoulos has a B.Sc degree in Physiology from McGill University, M.Sc. and Ph.D. degrees in Pharmacology from the Université de Montréal, and received her postdoctoral training at the LDI in the laboratory of Dr. Jacques Galipeau.
Dr. Eliopoulos is a scientist with expertise in adult stem/progenitor cells for cell and gene therapy of various diseases, such as kidney injury and cancer. Her research laboratory currently performs studies on the pre-treatment, gene-enhancement and therapeutic use of mesenchymal stem cells (MSCs).

Kolja Eppert

Assistant Professor
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  • Division of Experimental Medicine
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Kolja Eppert

Assistant Professor

Our work is focused on understanding the process of self-renewal in hematopoietic stem cells. In particular, we are interested in deciphering the molecular regulation of self-renewal in both normal and acute myeloid leukemia stem cells (LSCs) with the aims of disrupting leukemic development and enabling expansion of normal stem cells.

Carl Ernst

Assistant Professor
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  • Psychiatry
  • Douglas Research Center
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Carl Ernst

Assistant Professor
Department of Psychiatry

Carl Ernst, is currently a professor at McGill in the departments of Human Genetics, Neuroscience, and Psychology. The goal of his work is to study human behaviour and mood by identifying genes that may be involved in mental disorders. For this work, he produces cellular models based on the functions of specific genes, and screens at-risk populations for genetic mutations, deriving stem cells from their tissues. He then assesses how neurons derived from these subjects’ stem cells differ from neurons derived from healthy patients.

Dominique Farge

Adjunct Professor
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  • Medicine
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Dominique Farge

Adjunct Professor

Professor Dominique Farge has a long-standing commitment to the field of transplantation and stem cell therapy. She began her career as a physician and researcher in solid organ transplant where she made a number of important contributions and participated in ground breaking advancements, such as the world’s first triple transplant in cystic fibrosis. In the last 25 years she has focused on stem cell therapy in rare autoimmune diseases. She has conducted clinical and translational research, and participated in clinical activity, in hematopoietic stem cells transplantation (HSCT) and mesenchymal stem cell (MSC) therapy for autoimmune diseases. She has been involved in the development of several European guidelines for stem cell therapies: a) as a treatment for Scleroderma, b) for the use of stem cell transplantation in Autoimmune Diseases, and c) for the use of stem cell transplantation in Lupus. For the last 15 years she has worked at both French and European levels to coordinate several clinical and translational research programs on rare autoimmune diseases, including Systemic Sclerosis (SSc), Systemic Lupus Erythematosus (SLE), severe forms of Multiple Sclerosis (MS) and Crohn’s disease. She is a co-founding elected board member of the European Scleroderma Trials and Research Group (EUSTAR). She has been a member of the Autoimmune Diseases Working Party (ADWP) of the European Bone Marrow Transplant Association (EBMT) since 1998. She was nominated secretary of the ADWP in 2004 and then elected chair (voted by all EBMT members) from 2010 to 2013 and for a second mandate from 2013 to 2016. While coordinating the first clinical trials SSc (PI for PHRC for HSCT 1997, MSC 2011), SLE, MS, Diabetes and Crohn’s disease, she founded the French MATHEC (Maladies Auto Immunes et Thérapie Cellulaire) network dedicated to stem cell therapy in auto-immune disease, which has been labelled and funded as Center of Reference for Rare Autoimmune Diseases in Ile de France (2017 -2021).

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Edward Fon

M.D., FRCPC, Professor
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  • Neurology and Neurosurgery
  • MNI
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Edward Fon

M.D., FRCPC, Professor

Dr. Edward A. Fon is the Scientific Director of the Montreal Neurological Institute and Professor in the Department of Neurology and Neurosurgery at McGill University. He is a Clinician-Scientist and attending neurologist specializing in movement disorders. He is Director and co-founder of the FRQS Quebec Parkinson Network. His research focuses on the molecular events leading to the neuronal degeneration in Parkinson’s disease (PD). He is particularly interested in the function and cell biology of PD genes and has made some important contribution, published in prestigious journals. He also leads the Open Science Drug Discovery initiative at the Montreal Neurological Institute. Dr. Fon has received several awards during the course of his career including the CIHR Clinician-Scientist award, the Prix de Jeune Chercheur Blaise Pascal, a National Scholar award of the FRQS and the EJLB Foundation Scholar. He is an elected member of the American Society for Clinical Investigation (ASCI). His research is currently supported by the CIHR (Foundation grant), CQDM, Brain Canada, CCNA and the Michael J. Fox Foundation.

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Marco Gasparrini

M.Sc., Laboratory Manager
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  • Human Islet Transplant Laboratory
  • Surgery
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Marco Gasparrini

M.Sc., Laboratory Manager
Islet Transplant Program

Mr. Marco Gasparrini has been with the MHITL as a technical research assistant and responsible for the quality assurance and control of the program since 2010. He received his Bachelor of Science degree in Physiology at McGill University in 2008. His research focus on discovering novel therapeutic approaches to the development of beta-cells lead him to obtain a Master of Science degree in Experimental Medicine at McGill University in 2010. In 2017, he became the manager of the Human Islet Transplant Laboratory.

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Alexander Gregorieff

Assistant Professor
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  • Pathology
  • RI-MUHC
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Alexander Gregorieff

Assistant Professor

One of the extraordinary abilities of all living creatures is their capacity to repair damaged tissues following injury. This regenerative property is in large part due to the existence of stem cells that are defined by their ability to replace themselves through division, as well as giving rise to specialized cell types through a process known as differentiation. Unfortunately, once stem cells acquire mutations that cause them to proliferate incessantly, they can also fuel cancer growth. My lab focuses on the stem cells in the epithelial lining of our intestinal tract. By constantly replenishing the gut epithelium, intestinal stem cells ensure proper nutrient uptake and barrier formation against environmental toxins and pathogens throughout life. My interests lie in understanding the signals that control gut stem cell behaviour and how these signals become misregulated in diseases such as inflammatory bowel disease and colon cancer.

Luke Healy

Assistant Professor
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  • Neurology and Neurosurgery
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Luke Healy

Assistant Professor

Dr. Luke Healy completed a B.Sc. Neuroscience at University College of Cork (Ireland) and undertook his doctoral work at Trinity College Institute of Neuroscience in Trinity College Dublin. His Ph.D works focused on the pharmacologic effects of a new multiple sclerosis disease modifying therapy, Gilenya, on human astrocytes. During his Ph.D Dr. Healy spent a year at the Novartis Institute for Biomedical Research (Basel, Switzerland) studying the functional antagonism of a class of GPCRs, the sphingosine-1-phosphate receptor family. In 2014 Dr. Healy undertook his postdoctoral training in the laboratories of Drs. Jack Antel and Amit Bar-Or at the Montreal Neurological Institute (MNI) where he focused on the role of human myeloid cell populations in the pathogenesis of multiple sclerosis. His work using monocyte-derived-macrophages from patient populations in addition to primary human adult microglia derived from surgically resected tissues has shed light on the molecular processes of phagocytic uptake of myelin debris by these cell types. Dr. Healy was appointed as an Assistant Professor in the Department of Neurology and Neurosurgery at the MNI in March 2018. Guided by the use of primary human microglia and microglia derived from multiple sclerosis and neurodegenerative disease patient-derived iPSCs, his group examines how human microglia can provide a link between genetic risk factors, inflammation and neurodegenerative disease associated phenotypes. With the overarching aim of understanding human microglia activation, identifying novel therapeutic targets and using pharmacological tools to shift microglia functionality, in an effort to combat chronic microglial inflammation.

Terry Hébert

Professor
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  • Pharmacology and Therapeutics
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Terry Hébert

Professor

Terry Hébert’s research focus is on the ontogeny, formation and trafficking of GPCR-based signalling complexes with a view toward understanding the architecture, wiring and integration of individual GPCR signalling pathways both at the cell surface and in the nucleus. Our primary focus is in the context of cardiovascular disease. He has developed new methods for in cellulo measures of protein/protein interactions and is highly involved in the development of new multiplexed signalling assays for drug discovery. The lab is now poised to exploit patient-derived iSPC lines to develop personalized understanding of disease and its treatment.

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Corinne Hoesli

ing., Ph.D., Assistant Professor
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  • Chemical engineering
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Corinne Hoesli

ing., Ph.D., Assistant Professor

The Stem Cell Bioprocessing Laboratory works on engineering bioreactors for stem cell culture. We apply engineering approaches to design, optimize and scale up stem cell production systems. We are currently investigating the effects of various biomaterials and 3D culture on pluripotent stem cell differentiation into pancreatic cells as well as vascular endothelial cells. The main areas of applications of our research are diabetes cellular therapy and the development of vascular substitutes to treat cardiovascular disease.

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Arezu Jahani-Asl

Assistant Professor
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  • Oncology
  • LDI
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Arezu Jahani-Asl

Assistant Professor

The main goals of research in the Jahani Lab are to identify the molecular mechanisms that underlie the pathogenesis of brain tumor. In particular, the studies are focused on adult glioblastoma, a cancer of the brain for which, presently, there is no cure. Dr. Jahani is addressing how these tumors form and grow. She is using human brain tumor stem cells as well as mouse neural stem cells together with a combination of molecular and cell biology techniques and imaging to identify the fundamental principles and mechanisms that drives the tumorigeneic property of these tumor cells. These studies provide key steps towards understanding of key regulators of glioblastoma and how to target these key players in the cancerous brain.

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David Juncker

Professor
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  • Biological and Biomedical Engineering
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David Juncker

Professor

David Juncker, PhD, is a Full Professor and Chair of Biomedical Engineering at McGill University, and holds a Canadian Research Chair in Bioengineering. He leads the Micro and Nano-bioengineering lab that develops new technologies for multimodal biomarker discovery, including multiplex protein analysis, capture of circulating tumor cells and clusters, and single exosome analysis. David’s current interests are in the miniaturization and integration in biology and medicine, which includes the engineering and utilization of novel micro and nanotechnologies for manipulating, stimulating and studying oligonucleotides, proteins, cells, and tissues. The emerging field of nanobiotechnology, in a broad sense, is the most exciting to David, and is also key to tackle some of the major challenges in biology and medicine, for example identifying novel biomarkers for early disease diagnosis and developing low-cost point-of-care diagnostics. He has 78 publications and his work has been cited over 4645 times, with H-index 31 since 2001. He has 8 patents filed since 2014. Inventions from his research group have led to 3 active spin-offs.

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Mari Kaartinen

Associate Professor
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  • Division of Experimental Medicine
  • Dentistry
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Mari Kaartinen

Associate Professor

Dr. Kaartinen is an Associate professor at McGill University in the Faculties of Dentistry (Division of Biomedical Sciences) and Medicine (Division of Experimental Medicine, Department of Anatomy and Cell Biology). She has an MSc degree in Organic Chemistry from University of Jyvaskyla, Finland, and a PhD-degree (1999) in Biochemistry from the Department of Biochemistry and Biotechnology in University of Kuopio, Finland (currently University of Eastern Finland). She completed her postdoctoral training in bone and extracellular matrix biology in the Faculties of Medicine and Dentistry at McGill University, and joined McGill University as an Assistant Professor in 2002 and was promoted to Associate Professor in 2009. She has acted as Director of Biomedical Sciences in the Faculty of Dentistry and is interested in promoting critical thinking and academic integrity. Dr. Kaartinen has worked on transglutaminases, their substrates and roles in cellular differentiation for over 20 years and acted as the Chair of Gordon Research Conference on Transglutaminases in Human Disease Processes in 2018. She is a member of the Editorial Board for Cell Death and Disease.

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Amine Kamen

Professor
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  • Bioengineering
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Amine Kamen

Professor

Amine Kamen is Professor of Bioengineering at McGill University, and Canada Research Chair in Bioprocessing of Viral Vaccines. He is Researcher Emeritus of the National Research Council of Canada (NRC) where he was employed until early 2014, as head of the Process Development section of the Human Health Therapeutics Portfolio. At NRC, he established one of the North America largest and most advanced governmental center for animal cell culture addressing process development and scale up of biologics. Also, he developed with his team and licensed to industry multiple technology platforms for efficient manufacturing of recombinant proteins and viral vectors and vaccines and led technology transfer to manufacturing sites for clinical evaluation and commercialization.
His current research activities focus on uncovering mechanisms associated with cell production of viral vectors and viral vaccines; cell and metabolic engineering; process control and monitoring; and process analytical technologies of high yield productions of viral vectors for gene delivery and vaccination. He published over one hundred and fifty papers in refereed international journals and acts as consultant for several national and international private and public organizations.

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Jonathan Kimmelman

Professor
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  • Biomedical Ethics
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Jonathan Kimmelman

Professor

Jonathan Kimmelman, PhD, is James McGill Professor of Biomedical Ethics at McGill University, and directs the Biomedical Ethics Unit as well as his own research group, STREAM (Studies in Translation, Ethics and Medicine). Kimmelman’s research centers on ethical, policy, and scientific dimensions of clinical development. In addition to his book, Gene Transfer and the Ethics of First-in-Human Experiments (Cambridge Press, 2010), major publications have appeared in Science, JAMA, BMJ, and Hastings Center Report. Kimmelman received the Maud Menten New Investigator Prize (2006), a CIHR New Investigator Award (2008), a Humboldt Bessel Award (2014), and was elected a Hastings Center Fellow (2018). He has sat on various advisory bodies within the U.S. NHLBI and NIAID, served for four tours of duty on U.S. National Academies of Medicine committees, and chaired the International Society of Stem Cell Research Guidelines for Stem Cell Research and Clinical Translation revision task force 2015-16. His research has been covered in major media outlets, including NPR’s All Things Considered, STATNews, and Nature. Kimmelman is deputy editor at Clinical Trials, and serves as an associate editor at PLoS Biology.

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Irah King

Associate Professor
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  • Microbiology and Immunology
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Irah King

Associate Professor

The focus of our research is to understand how immune cells communicate with their local environment to promote protective immune responses relevant to human disease. We are particularly interested in immunity at barrier sites such as the gut, skin and lung as these tissues face the complex task of maintaining homeostasis while directly interacting with the outside world.
Ongoing studies include:

  • The molecular mechanisms of CD4+ T cell differentiation following intestinal helminth infection.
  • The gut-lung axis in the context of infectious disease
  • Innate immune mechanisms of disease tolerance during intestinal helminth infection.
  • Regulation of skin-resident IL-17-producing T cells in the context of psoriatic-like inflammation.
  • The impact of the microbiome on infection and inflammatory bowel diseases.
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J. Matt Kinsella

Associate Professor
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  • Bioengineering
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J. Matt Kinsella

Associate Professor

J. Matt Kinsella is an Associate Professor of Bioengineering at McGill University. The Kinsella lab investigates developing bioprinted tissue-engineered in vitro disease models of tumors using patient-derived materials. We are using these bioprinted platforms to explore fundamental disease pathways that may instruct multiscale systems-engineering treatment approaches integrating nanomedicine, tissue engineering, and bioprinting.

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Erika Kleiderman

Academic Associate
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  • Human Genetics
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Erika Kleiderman

Academic Associate

Erika Kleiderman is a lawyer and an Academic Associate at the Centre of Genomics and Policy at McGill University. Her research deals with the ethical, legal, and social implications surrounding access to data and genetic information, biobanking, and the regulation of stem cells, regenerative medicine, and new reproductive technologies. Erika is involved with the Stem Cell Network’s Trainee Communications and Training & Education Committees, as well as the coordinator of the pan-Canadian initiative aimed at assessing the adequacy of existing regulatory frameworks and considerations for reframing the Assisted Human Reproduction Act, in light of evolving reproductive technologies. She is also the Coordinator of the Canadian International Data Sharing Initiative (Can-SHARE) and the Access Officer of the Canadian Partnership for Tomorrow Project (CPTP). Erika’s interests expand to the potential implications of gene therapy / enhancement in minors within a sporting context.

David Labbé

Assistant Professor
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  • Surgery
  • RI-MUHC
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David Labbé

Assistant Professor

Systemic metabolic alterations associated with increased consumption of saturated fat and obesity are linked with increased risk of prostate cancer progression and mortality, but the molecular underpinnings of this association are poorly understood. My research program is aimed at understanding the combination of key tumour genetic alterations together with the host characteristics required for diet to alter prostate cancer progression. This will allow the identification of new therapeutic targets and the elaboration of novel therapeutic approaches devised to treat prostate cancer patients at risk of progression to an aggressive, lethal disease. More specifically, my research focuses on the mechanisms and therapeutic targets related to epigenetic alterations and uses murine and human cell lines, animal models (including genetically engineered mouse models) and human tissues.

Jianyu Li

Assistant Professor
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  • Mechanical Engineering
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Jianyu Li

Assistant Professor

Dr. Jianyu Li is an Assistant Professor in the Department of Mechanical Engineering, an Associate Member of Biomedical Engineering Department at McGill University. His research interests include biomaterials, mechanics, soft machines, drug delivery, cellular and tissue engineering.

Nicole Li-Jessen

Assistant Professor
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  • Biological and Biomedical Engineering
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Nicole Li-Jessen

Assistant Professor

My work involves the investigation of laryngeal tissue regeneration by manipulating the behavior of vocal fold fibroblasts, which are recently found to display cell surface markers and multipotent differentiation characteristics as of mesenchymal stem cells. A combined wet lab and computational approach is used to understand and predict the complex response of the cells in response to chemical and mechanical environment.

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Luc Mongeau

Professor
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  • Mechanical Engineering
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Luc Mongeau

Professor

Luc Mongeau is Professor of Mechanical Engineering at McGill University.  He obtained his B.Eng. and M. Eng. Degrees from the University of Montreal at Ecole Polytechnique in 1884 and 1986.  He received a Ph.D. In Acoustics from the Pennsylvania State University in 1991. After working for two years as postdoctoral member of technical staff at AT&T Bell Laboratories, he joined the School of Mechanical Engineering at Purdue University.  There he worked as Assistant, Associate, and Full Professor at the Ray W. Herrick Laboratories in Noise and Vibration Control and in Biomechanics.  He has joined McGill in 2006 and has been engaged in research on the biomechanics of voice production, biomaterials for tissue regeneration, computational and physical models of drug delivery, wound healing, and cell motility. He is a Tier I Canada Research Chair, a Fellow of the Acoustical Society of America, and a member of ASME, SAE, AIAA, CSB, ESB, ASEE, and other societies. Many graduate students have worked under his supervision and are now employed in academia and industry. He has published over 120 archival journal publications in over 40 different journals.

Christopher Moraes

Assistant Professor
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  • Chemical engineering
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Christopher Moraes

Assistant Professor

The Moraes lab develops high-throughput microengineered systems to study the role of the stem cell microenvironment on differentiation and development processes. These approaches combine biomaterial design, tissue engineering, and advanced optical imaging techniques to enable high-throughput, high-content and high-precision analysis of cell-matrix interactions.

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Makoto Nagano

Associate Professor
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  • Obstetrics and Gynecology
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Makoto Nagano

Associate Professor

The term, “stem cell”, first emerged in 1868 in context of evolution and fertilization/ embryogenesis while the history of germline stem cells starts in 1885. McGill has a strong background in stem cell research, pioneered by Dr. Charles Leblond, particularly for male germline stem cells, also called spermatogonial stem cells (SSC). Following this McGill tradition, my research focuses on biology and applications of SSCs for male fertility preservation and restoration in childhood cancer patients. I started the SSC research in 1995 with Ralph L. Brinster at the University of Pennsylvania and have contributed to establishing the foundation of SSC research, including developing the transplantation assay, SSC culture system, xenotransplantation of primate and human SSCS, and animal transgenesis through genetic modifications of SSCs, defining the homing efficiency of SSCs after transplantation and the absolute number of SSCs, establishing an in-vitro SSC detection assay, revealing SSC aging, and demonstrating the involvement of Wnt signaling in SSC fate control. Currently, we are working on purification and molecular characterization of mouse and human SSCs, development of novel compounds that improve the efficiency of SSC homing, and establishment of human SSC culture systems in the two-dimensional and microfluidics formats.

Anastasia Nijnik

Assistant Professor
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  • Physiology
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Anastasia Nijnik

Assistant Professor

Anastasia Nijnik (Nyzhnyk) is a Tier 2 Canada Research Chair in Hematopoiesis and Lymphocyte Differentiation, and since 2011 an Assistant Professor in the Department of Physiology and a member of the McGill Complex Traits Group. Her research program studies the biology of hematopoietic stem cells, including epigenetic regulation of gene expression, genetic stability and leukocyte differentiation, using transgenic mouse models. Specifically the current program is focused on the chromatin-binding deubiquitinase MYSM1 and its activities in transcriptional regulation and DNA damage response signalling in hematopoiesis.

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Steven Paraskevas

M.D., Associate Professor
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  • Human Islet Transplant Laboratory
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Steven Paraskevas

M.D., Associate Professor

Dr. Paraskevas is currently Associate Professor of Surgery, Director of the Pancreas and Islet Transplant Program and Director of the Human Islet Transplantation Laboratory. Dr. Paraskevas’ research interests include the study of beta-cell injury and cell survival and how cell injury induces the recipient’s immune response. He is working with collaborators on novel agents for promotion of beta-cell survival as well as measures to improve islet engraftment and function.

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William Pastor

Assistant Professor
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  • Biochemistry
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William Pastor

Assistant Professor

Dr. William Pastor has been an assistant professor at the Department of Biochemistry at McGill University since January 2018. His lab uses stem cell models to study transcriptional and epigenetic regulation during human developmental processes. Dr. Pastor’s current projects are 1) Studying transcriptional control of placental stem cell specification and homeostasis 2) Determining how DNA methyltransferases are regulated during early embryogenesis.

Jerry Pelletier

Professor
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  • Biochemistry
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Jerry Pelletier

Professor

Jerry Pelletier is a James McGill Professor in the Departments of Biochemistry and Oncology at McGill University and a member of The Rosalind and Morris Goodman Cancer Research Center. His interest is on diverse aspects of eukaryotic translation initiation – with a recent focus on applying chemical biology and genetic tools to better understand the molecular mechanisms that regulate ribosome recruitment to mRNAs.
Research:
• We have applied a chemical genomic approach to identify novel compounds that inhibit translation initiation and to which tumor cells appear particularly sensitive. We have characterized the mode of action of these molecules, identified their biological targets, and assessed their efficacy in pre-clinical cancer models. We currently have a Research Program to assess their effects on the translation footprint in different cancer cells, determine how they are capable of reversing drug resistance in certain settings, assessing their consequences on the tumor-host crosstalk and impact on tumor heterogeneity.
• We are using CRISPR-Cas9 to establish phenotype-based high throughput screens for difficult to drug targets. Our current is focused on c-MYC expression expression inhibitors but or gene tracing platform can be adapted to any expressed locus of interest in search for expression inhibitors.
• We are manipulating the organizing principles of translation. Using synthetic biology approaches, coupled with the RNA targeting capabilities of CRISPR-Cas9, we are developing new approaches by which to redirect the translation initiation apparatus to specific mRNAs and to pre-defined addresses on these templates. The ability to manipulate the gene expression pathway has unique advantages to treating genetic disorders.

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Linda Peltier

RN Ph.D., Manager of the Cellular Therapy Laboratory
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  • RI-MUHC
  • Cellular Therapy Laboratory
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Linda Peltier

RN Ph.D., Manager of the Cellular Therapy Laboratory

In collaboration with Dr Pierre Laneuville, our laboratory is specialised in cord blood unit (CBU) processing and cryopreservation for laboratory and clinical research. We focus on maximising use of cord blood stem cells and cord tissue mesenchymal stem cells from donations rejected by public banks. Our priority is to better understand the role of the purified CD34+ cells in CBU pooling and in the simplification of the pooling method to make multicentre research protocols. Future laboratory and clinical studies will focus on cord tissue mesenchymal stem cells for cellular therapy and regenerative medicine.

Anie Philip

Professor
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  • Surgery
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Anie Philip

Professor

My research focuses on understanding the role of TGF-beta signaling in wound healing and scarring in the skin, and in the maintenance and repair of cartilage. In the cartilage, our studies center on understanding how the functional interplay between TGF-beta receptors and co-receptors regulates chondrocyte phenotype and function, in healthy and osteoarthritic cartilage. Our research on skin focuses on TGF-beta co-receptors as regulators of TGF-beta signaling in skin cells. We have recently shown that CD109, a novel TGF-beta co-receptor that we have identified in skin cells, inhibits TGF-beta signaling and displays potent anti-fibrotic properties in vitro and in vivo. One of our major objectives is to develop CD109-based peptides as TGF-b antagonists and anti-fibrotic agents for the treatment of pathological conditions such as hypertrophic scarring and scleroderma. Research in my laboratory is funded by the Canadian Institute for Health Research (CIHR), NSERC and United States Department of Defense.

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Ciriaco Piccirillo

Professor
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  • Microbiology and Immunology
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Ciriaco Piccirillo

Professor

Dr. Piccirillo is Professor in the Departments of Microbiology and Immunology, and Medicine of McGill University. He is the Director of the Centre of Excellence in Translational Immunology (CETI) at McGill and MUHC, and the nominated Leader for the Translational Immunology theme in the Program in Infectious Diseases and Immunity in Global Health (IDIGH). He is Senior Scientist and Principal Investigator of the IDIGH Laboratory of Immunoregulation. Finally, he the Director of the ImmunoPhenotyping Platform for the RI-MUHC, a state-of-the-art technological core providing expert advice and training in multi-parametric flow cytometry and cell sorting.
Dr. Piccirillo leads an internationally recognized research program which focuses on the immune regulation of autoimmune, infectious and inflammatory diseases. His research tries to harness the power of the immune system to boost, stop or restore T cell function in autoimmune/inflammatory diseases, cancers or immunodeficiencies, respectively. His research is responsible for many seminal and pioneering studies in a variety of animal models, non-human primates and humans. His current research program makes use of a variety of mouse models and in human subjects to monitor and characterize the development and functional dynamics of T cell function in health and disease. His research program also focuses on the development of novel immunotherapeutic strategies to monitor and manipulate Foxp3+ Treg cell function and ultimately modulate immune responses in infectious, autoimmune and inflammatory disorders.

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Dieter Reinhardt

Professor
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  • Anatomy and Cell Biology
  • Dentistry
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Dieter Reinhardt

Professor

Dr. Reinhardt was recruited in 2004 as an Associate Professor to McGill University with a cross-appointment between the Dept. of Anatomy and Cell Biology of the Faculty of Medicine and the Faculty of Dentistry. Since 2011, he is a Full Professor at McGill University exploring how cells form, maintain and functionally interact with extracellular matrices in the cardiovasculature, bone, skin, and the eye. Mutations in extracellular components of these tissues cause human hereditable connective tissue disorders. His goal is to identify fundamental mechanisms, and new strategies to diagnose, monitor and treat these disorders. Since 2006, Dr. Reinhardt holds a Canada Research Chair Tier 1 Award in Cell-Matrix Biology, which was renewed in 2013. He is a founding member of the Canadian Connective Tissue Society and has active roles in several other international scholarly societies.

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Derek Rosenzweig

Assistant Professor
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  • Experimental Surgery
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Derek Rosenzweig

Assistant Professor

Dr. Derek Rosenzweig received his Ph.D. in 2008 in Molecular and Cellular Pharmacology (G protein signalling in retina) at University of Miami in Florida. He pursued his postdoctoral fellowship in tissue engineering/mechanobiology approaches to cartilage repair at McGill with Tom Quinn in Department of Chemical Engineering and then in biomaterials approaches to intervertebral disc repair with Lisbet Haglund in Orthopaedic Surgery at McGill. He was a Research Associate with McGill Scoliosis and Spine group for 2 years focusing on 3D printing for soft tissue and bone repair. He became an Assistant Professor in Experimental Surgery at McGill in July 2017. His multidisciplinary research program combines materials science, engineering, bioengineering, surgical oncology and cell biology approaches for biofabrication and 3D printing scaffolds for anti-cancer therapeutic delivery. These devices are intended for tissue repair and regeneration following tumor resection and/or bone trauma. He also focuses on modeling the human bone tumor microenvironment using lab-on-a-chip bioprinting technology. The lab uses clinically relevant patient derived bone metastases cells arising from breast, lung and prostate cancer.

Funding from Research Institute McGill University Health Centre, Canadian Cancer Research Society, MITACs and Le Réseau de recherche en santé buccodentaire et osseuse (RSBO).

John S. Sampalis

Associate Professor
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  • Experimental Surgery
  • RI-MUHC
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John S. Sampalis

Associate Professor

Dr. Sampalis is founder and CEO of JSS Medical Research founded in 1997. He is a Tenured Professor of Surgery and Epidemiology at McGill University & University of Montreal and Laval, and is recognized as one of Canada’s leading epidemiologists, as well as the top trauma researcher. His research objectives include: to develop research projects that will guide the evolution of trauma care and to incorporate clinical and patient outcomes as well as economic evaluation in trauma care research.

Reza Sharif-Naeini

Associate Professor
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  • Physiology
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Reza Sharif-Naeini

Associate Professor

Dr. Sharif’s lab is interested in understanding the molecular bases of mechanotransduction, and the role of mechanosensory neurons in normal and pathological pain transmission. There are three main themes: 1) the identification of the genes encoding mechanosensitive ion channels (MSCs) in mammals. 2) Defining the role of MSCs in physiology and pathophysiological conditions 3) Defining the neuronal circuits in the spinal cord and how changes in the function of these networks changes in the setting of chronic pain.

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Jesper Sjöström

Associate Professor
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  • Medicine
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Jesper Sjöström

Associate Professor

Jesper Sjöström is associate professor in neuroscience at McGill University, where his team explores plasticity in the brain using 2-photon imaging, quadruple patching, optogenetics, and computer modelling. After an MSc in molecular biotechnology at Uppsala University in 1996, he obtained a PhD in neuroscience at Brandeis University in 2003. Following four years of postdoctoral studies at University College London, he remained as an MRC CDF awardee running his own lab. After arriving at McGill in 2011, he received the CIHR New Investigator and the FRQS Chercheur-Boursier awards. His research has unveiled plasticity learning rules, neocortical connectivity patterns, and unorthodox forms of NMDA receptor signalling. He is chief editor of Frontiers in Synaptic Neuroscience.

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Vahab D. Soleimani

Assistant Professor
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  • Human Genetics
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Vahab D. Soleimani

Assistant Professor

My research program is focused on uncovering the epigenetic and transcriptional machinery that regulates stem cell self-renewal and differentiation using skeletal muscle regeneration as a model. Loss of stem cell or their diminished function underlies numerous muscle-wasting diseases. We are interested in identifying relevant molecular pathways that can be targeted by specific drugs to boost muscle stem cell self-renewal and expansion as a therapeutic strategy to treat muscle wasting-diseases.

Nahum Sonenberg

Professor
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  • Biochemistry
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Nahum Sonenberg

Professor

Dr. Sonenberg studies the molecular basis of the control of protein synthesis in eukaryotic cells and its importance in diseases such as cancer, obesity, diabetes and neurological diseases. His research focuses primarily on the elucidation of the mechanism of translation initiation in eukaryotes and its regulation during development, differentiation and neoplasia. Dr. Sonenberg carried out pioneering and fundamental work that laid the basis for the understanding of how translation initiation factors promote ribosome binding, and the regulation of initiation factor activity by extracellular stimuli (growth factors, hormones, G-protein-coupled receptor agonists, cytokines and mitogens), and viruses. He made seminal discoveries demonstrating that control of translation initiation is implicated in cancer, learning and memory, autism and fragile X-syndrome.

Jo Anne Stratton

Assistant Professor
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  • Neurology and Neurosurgery
  • MNI
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Jo Anne Stratton

Assistant Professor

Jo Anne Stratton’s research interests are inspired by the complex and context-dependent interactions of immune cells within the nervous system which function to modulate regeneration and plasticity, but can also underlie pathologies such as demyelination and axonal degeneration leading to cognitive impairment and sensory/motor deficits. Her research platform spans basic in vitro cell culture interrogation of cellular interactions, to transgenic animal models which recapitulate responses to different injuries and diseases, to human cellular and histological analyses.

Maryam Tabrizian

Professor
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  • Biological and Biomedical Engineering
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Maryam Tabrizian

Professor

Maryam Tabrizian is professor in the Biomedical Engineering Department and the Faculty of Dentistry, and James McGill professor at McGill University. She became FRSQ-Chercheure nationale awardee (2006), Guggenheim Fellow in Biomedical Sciences (2010), the Fellow of the Biomaterials Science & Engineering (2011) and Fellow of Royal Society of Canada-Academy of Science (2017) for her contribution to the field of Biomedical Engineering and Biomedical Sciences. She has established expertise in the design of nano-biomaterials and nano-biointerfaces for their application in nanomedicine, regenerative medicine and Lab-on-a-chip devices. She was the director of the Centre for Biorecognition and Biosensors (CBB) for 10 years that she founded in 2001. She is the author of over 220 peer-reviewed papers (H-index 60), 100 invited lectures, many book chapters, patents, and over 330 communications. She is currently the Editor-in-Chief of Materials (MDPI ISSN 1996-1944; CODEN: MATEG9).

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Jean Tchervenkov

M.D., FRCSsC, Associate Professor
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  • Surgery
  • RI-MUHC
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Jean Tchervenkov

M.D., FRCSsC, Associate Professor

Jean I. Tchervenkov, MD, FRCSsC, FACS, is Associate Professor of Surgery at the McGill University Health Centre in Montreal, Quebec. He is currently the Director of Live Donor Kidney Transplantation Services at the Victoria Hospital and Director of Pediatric Transplantation at The Montreal Children’s Hospital. His main research activities are in the areas of solid organ transplantation and immunosuppression. Dr. Tchervenkov has over 100 publications in peer reviewed medical journals and has presented over 150 abstracts. Dr. Tchervenkov graduated from McGill University, and came on staff at the Hospital in 1990. He is President of MD Specialists in Montreal.

Simon Tran

Professor
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  • Dentistry
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Simon Tran

Professor

Dr. Tran is experienced in all three fields of research: basic science, translational research, and clinical studies. He is committed to the training of graduate and postdoctoral students in the area of stem cell biology and tissue engineering. The aim of this laboratory is to identify, isolate, and characterize post-natal stem cells of the craniofacial complex (such as salivary and periodontal stem cells). We are also working on the growth and behavior of post-natal stem cell on different 3-D tissue engineered matrices. Our hypothesis is that post-natal stem cells from one tissue (such as stem cells from the bone marrow) can differentiate into cells of another tissue (such as the salivary gland) and how to translate this phenomenon into clinically useful therapies to regenerate lost salivary gland tissue of patients experiencing the disabling effects of a dry mouth (i.e. reduced salivary secretion) due to Sjogren’s Syndrome or to the damage caused to the salivary glands following irradiation treatment for head and neck cancer. In addition to providing a new understanding of tissue dynamics in health and disease, the Tran’s laboratory presents unique possibilities for the emerging field of regenerative medicine.

Michel L. Tremblay

F.R.S.C., Professor
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  • Biochemistry
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Michel L. Tremblay

F.R.S.C., Professor

Dr. Michel L. Tremblay, Ph.D. is a James McGill Professor and former director of the Goodman Cancer Research Centre His laboratory works on characterizing the function and regulation of several members of the Protein Tyrosine Phosphatase (PTP) gene family using both biochemical and genetic approaches. Dr. Tremblay’s lab is also developing several new approaches towards PTP inhibition, as well as large siRNA gene family screens in order to uncover potential applications of these in various diseases (diabetes, obesity, spinal cord injury, neural degenerative diseases, intestinal bowel diseases and other inflammatory diseases), particularly in human cancers.

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Jean-François Trempe

Associate Professor
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  • Pharmacology and Therapeutics
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Jean-François Trempe

Associate Professor

Jean-Francois Trempe obtained his doctorate degree from the University of Oxford in 2007. After postdoctoral training at McGill and the Montreal Neurological Institute, he obtained a Faculty position at McGill in 2013. His goal is to elucidate the function of proteins implicated in Parkinson’s disease (PD) through 3D structure determination and proteomics studies, as well as design small molecules to modulate their activities. In collaboration with the Michael J. Fox Foundation and the SGC, his lab aims to design and characterize small-molecules activators for Parkin and PINK1. He holds a Tier 2 Canada Research Chair in Structural Pharmacology and has received the New Investigator Award from Parkinson Canada in 2014. He has published a total of 48 articles during his career (H-index 24, 2692 citations), mostly on the topics of ubiquitin and neurodegenerative diseases. His most important contribution to date is the structure determination of Parkin, published in Science in 2013, which revealed the mechanism of action of this important PD target.

Donald Vinh

M.D., FRCP, FACP, Associate Professor
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  • Infectious Diseases
  • RI-MUHC
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Donald Vinh

M.D., FRCP, FACP, Associate Professor

Dr. Vinh is an Infectious Disease specialist and Medical Microbiologist at the MUHC, and FRQS Clinician-scientist with a translational research program at the RI-MUHC focusing on human genetic susceptibility to infectious diseases.

Simon Wing

M.D., FRCPC, Professor
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  • Division of Endocrinology and Metabolism
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Simon Wing

M.D., FRCPC, Professor

My laboratory explores the roles of the ubiquitin system in vivo. We are particularly interested in its roles in muscle growth and atrophy as well as its roles in spermatogenesis. Our recent studies implicate the ubiquitin system in regulating the activity and differentiation of muscle stem cells – the satellite cells- as well as in the establishment of a maintenance of spermatogonial stem cells. Harnessing the potential of these stem cells may lead to novel approaches to the treatment of muscle wasting as well as to the protection of fertility in men who will undergo either sterilizing radiation or chemotherapy.

Yojiro Yamanaka

Associate Professor
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  • Human Genetics
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Yojiro Yamanaka

Associate Professor

Our research interest is centered around how pluripotency is established and maintained in development and embryonic stem cells (ESCs). Using live imaging and modern genetic tools like CRISPR-Cas9, we are currently studying molecular mechanisms links of cell morphology, 3D cell positioning and gene regulation, which are tightly associated with pluripotency.

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