Research Scientist Position at Telescope Therapeutics

Position: Research Scientist

Primary Duties: Telescope Therapeutic is seeking to recruit a research scientist to work on a collaborative project involving the use of patient-derived induced pluripotent stem cells as a “state-of-the-art” model to test therapeutic candidates for heart disease. The project aims to deeply phenotype patient-derived cardiomyocytes to gain molecular and mechanistic understanding of the disease using various techniques. The end goal of the project is to evaluate the efficacy of drug candidates that aim to normalize cardiac function in heart disease.

• Responsibilities may include:
• Generation, culture and maintenance of primary neonatal rat cardiomyocytes and fibroblasts
• Culture and maintenance of control and patient-derived iPSC lines in parallel
• Differentiation, maturation and long-term maintenance of iPSC-cardiomyocyte cultures
• Assisting in optimization of assays measuring impedance, extracellular field potentials and electrophysiological properties of iPSC-cardiomyocytes
• Assisting with planning, development and data analysis of FRET-based signalling assays and high-content microscropy

Education and Experience: Suitable applicants should have a master’s degree and research experience in a related discipline. Experience with cardiac cell models is a must, with preference for candidates with experience in primary or iPSC cell culture and cardiac differentiation, patch clamp and electrophysiology, or other techniques commonly used in the cardiac field. Fluorescence microscopy, experience with FRET-based assays and molecular biology knowledge is a plus.

Salary: Commensurate with experience.
Duration: 1 year; Possibly renewable, depending on performance.
Send CV to: Terry Hébert terence.hebert@mcgill.ca

About Telescope Therapeutics:

The mission of TT is to use disease in a dish, iPSC-based models to treat disease:

1. Test existing medications (approved or unapproved) for responses at the individual or cluster level
2. Create new medical therapies for personalized responses at the individual or cluster level
3. Predict and treat medical conditions before they become overt disease
4. Help prepare today for the future of regenerative medicine tomorrow