Lady Davis Institute Distinguished Lecture Series: Paul S. Frenette, M.D.

Hematopoietic stem cell microenvironments in health and disease

Tuesday, October 1, 2019
12:00 pm – 1:00 pm
LDI BLOOMFIELD LECTURE HALL, F-4 (Ground Floor)

Professor Paul Frenette

Paul Frenette is the founding Director and Chair of the Ruth L. and David S. Gottesman Institute for Stem
Cell and Regenerative Medicine at Albert Einstein College of Medicine. His research interests have
concerned on the stem cell microenvironments in health and cancer, and the vascular biology in sickle cell
disease. His laboratory has also shown that neutrophils were direct participants in the vaso-occlusive
episodes that characterize sickle cell disease and identified molecular targets that are currently evaluated
in phase 3 clinical trials. His laboratory has also uncovered the critical role of the sympathetic nervous
system in the regulation of hematopoietic stem cell (HSC) egress from their niches, in the pathogenesis of
acute myeloid leukemia and prostate cancer. He has elucidated circadian rhythmicity in stem cell release
from the bone marrow, and identified cellular constituents forming niches in the bone marrow. Dr. Frenette
was elected member of the American Society for Clinical Investigation (2004) and of the Association of
American Physicians (2010). He has served on several editorial and institutional boards, Scientific
Committees of the American Society of Hematology, multiple panels at the NIH, and was President of the
International Society of Experimental Hematology (ISEH) in 2015.

Host: Dr. Alexandre Orthwein (514) 340-8222 x24252 / e-mail: alexandre.orthwein@mcgill.ca